Update on Ferroportin Regulation
نویسندگان
چکیده
منابع مشابه
Ferroportin and Erythroid Cells: An Update
In recent years there have been major advances in our knowledge of the regulation of iron metabolism that have had implications for understanding the pathophysiology of some human disorders like beta-thalassemia and other iron overload diseases. However, little is known about the relationship among ineffective erythropoiesis, the role of iron-regulatory genes, and tissue iron distribution in be...
متن کاملHuman mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation.
Mutations in the iron exporter ferroportin (Fpn) result in iron overload in macrophages or hepatocytes depending upon the mutation. Patients with Fpn mutation D157G show high serum ferritin and normal to slightly elevated transferrin saturation. Here, we show that Fpn(D157G)-green fluorescent protein (GFP) is down-regulated independent of hepcidin, and that this down-regulation is due to the co...
متن کاملUpdate on adipose tissue blood flow regulation.
According to Fick's principle, any metabolic or hormonal exchange through a given tissue depends on the product of the blood flow to that tissue and the arteriovenous difference. The proper function of adipose tissue relies on adequate adipose tissue blood flow (ATBF), which determines the influx and efflux of metabolites as well as regulatory endocrine signals. Adequate functioning of adipose ...
متن کاملIroning out Ferroportin.
Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis. All iron transfer to plasma occurs through t...
متن کاملPediatric Ferroportin Disease
From the Servicio d Guadalajara, Guadal lidades Médicas, U zServicio de Radiolo dalajara, and the §In Madrid, Spain. Address correspondence Jiménez, PhD, Cen Hospital 12 de Octub (e-mail: moranjimen The authors report no co Copyright # 2016 by E Hepatology, and Nu Gastroenterology, H article distributed un tion-Non Commerci where it is permissib properly cited. The commercially withou DOI: 10.1...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2020-133056